The expression of enhancer RNAs (eRNAs) is important for enhancer activation. As eRNAs are non-polyadenylated, Shiekhattar and colleagues studied the role of the Integrator complex, which is required for the 3′-end processing of other non-polyadenylated RNAs, in their biogenesis. They found that addition of epidermal growth factor (EGF) to HeLa cells resulted in Integrator recruitment to EGF-responsive enhancers and the induction of eRNA expression. When the Integrator subunit INTS11 was depleted, unprocessed eRNAs accumulated, the formation of EGF-dependent interactions between enhancers and promoters was abrogated, and the expression of EGF-responsive genes was reduced. The ectopic expression of wild-type, but not catalytically inactive, INTS11 restored EGF-dependent eRNA and gene expression, indicating that defects in eRNA processing contribute to the loss of transcriptional responsiveness to signalling cues.